Comparisons · 13 min read
BPC-157 vs TB-500: Research Peptide Comparison Reference
Side-by-side scientific reference comparing BPC-157 and TB-500: sequence, molecular weight, mechanism studied in preclinical literature, half-life, reconstitution, and storage. For research use only.
BPC-157 vs TB-500
For research use only. Not for human consumption. Not for diagnostic or therapeutic use.
BPC-157 and TB-500 are two of the most-cited soft-tissue research peptides in preclinical literature. They are frequently confused, but they are chemically and mechanistically distinct. This reference compares them side by side as research materials.
Side-by-side reference
| Property | BPC-157 | TB-500 |
|---|---|---|
| Amino acids | 15 | 17 |
| Sequence | GEPPPGKPADDAGLV | LKKTETQ (active fragment of Thymosin β4) |
| Molecular weight | ~1419 Da | ~889 Da |
| Origin | Stable gastric pentadecapeptide fragment | Synthetic fragment of Thymosin β4 |
| Solubility | Water-soluble | Water-soluble |
| Typical reconstitution | Bacteriostatic water | Bacteriostatic water |
| Recommended storage (lyophilized) | −20 °C, sealed, dark | −20 °C, sealed, dark |
| Recommended storage (reconstituted) | 2–8 °C, ≤4 weeks | 2–8 °C, ≤4 weeks |
| Preclinical pathways studied | Tendon, ligament, gastric mucosa | Actin-binding, angiogenesis |
1. BPC-157 reference
BPC-157 (Body Protection Compound-157) is a 15-residue peptide first isolated as a partial sequence of a protein identified in gastric juice. Preclinical literature has examined its activity on soft-tissue repair pathways and gastrointestinal mucosa in animal and in-vitro models.
2. TB-500 reference
TB-500 is a synthetic fragment of Thymosin β4 (Tβ4), a 43-amino-acid peptide that is the major actin-sequestering molecule in mammalian cells. The TB-500 fragment corresponds to the active actin-binding region (LKKTETQ). Preclinical literature has examined Tβ4 and TB-500 in models of angiogenesis, cellular migration, and wound contexts.
3. Storage and reconstitution
Both peptides are supplied lyophilized in sealed vials. Recommended handling:
- Store sealed vials at −20 °C, protected from light.
- Reconstitute with bacteriostatic water at the concentration required by the study protocol.
- After reconstitution, store at 2–8 °C and use within 4 weeks.
- Avoid freeze-thaw cycles of the reconstituted solution.
See the Reconstitution Guide for solvent volumes and the Dosing Calculator for concentration math.
4. Quality control expectations
Both peptides should ship with a current Certificate of Analysis showing ≥99% HPLC purity and mass-spec confirmation of the correct sequence. See How to Verify Peptide Purity.
5. Related references
All Peptide Logix products are supplied for research use only.
Frequently Asked Questions
What is the difference between BPC-157 and TB-500?+
BPC-157 is a 15-amino-acid fragment derived from a sequence identified in gastric juice and is studied in preclinical literature for soft-tissue repair pathways. TB-500 is a synthetic 17-amino-acid fragment of Thymosin β4 studied for actin-binding and angiogenesis pathways.
Which is more stable in solution?+
Both peptides are typically reconstituted in bacteriostatic water and refrigerated at 2–8 °C, with most laboratories reporting 4 weeks of solution stability when handled correctly.
Are these peptides interchangeable?+
No. BPC-157 and TB-500 are chemically and mechanistically distinct. They are studied as separate reference materials and should not be substituted in a study design.